Date and Time: June 28 (Wed.), 2023, 15:30 – 17:00
Place: E4-802 + Zoom (Hybrid)
Speaker: Martijn Cloos (Associate Professor, Ultra High Field Facility Fellow, Centre for Advanced Imaging, The University of Queensland, Australia)
Chair: Yoichi Miyawaki Professor
Title: BOLD fMRI and beyond
Abstract: In this talk I will discuss some of my lab’s efforts to explore the temporal specificity of functional Magnetic Resonance Imaging (fMRI) methods, including Blood Oxygen Level Dependent (BOLD) fMRI, Diffusion fMRI (DfMRI), and Direct Imaging of Neuronal Activity (DIANA). The first part will focus on gradient echo BOLD fMRI. BOLD fMRI signals reflect hemodynamic changes in response to neuronal activity. The spatial and temporal specificity of BOLD fMRI is therefore, in part, shaped by the vascular system. The spatial specificity of BOLD fMRI has been studied extensi vely using high resolution fMRI, but the temporal dynamics at high temporal frequencies are less well explored. Therefore, we investigated high frequency stimulus driven BOLD signals in two functionally and vascularly distinct cortical areas (somatosensory (S1) and motor (M1)). The second part will focus on DfMRI. DfMRI aims to create fMRI signals that reflect neuronal activity more directly. However, the DfMRI sequence has many similarities with the spin-echo
BOLD. Indeed, many attempts at DfMRI revealed BOLD like functional signals. We endeavoured to minimize BOLD contaminations in DfMRI to reveal distinct DfMRI signal components. In the final part of this talk will discuss our initial experiences with DIANA in human subjects and even more recently in rats and human brain organoids.
Participation Method: Zoom Pre-Registration Address